Novel potential nanostructures for photodynamic therapy

GARCIA, PABLO; PEREZ, LUIS; CORONADO, EDUARDO; ARGÜELLO, GERARDO

Photodiagnosis Photodynamic Therapy

ELSEVIER SCIENCE BV

Año: 2015 vol. 12

1572-1000

imers could be very effective for generating photothermaldamage because the excitation of the surface plasmon resonance(SPR) results in a temperature increase near the NP surface. Inaddition they present the advantage that the frequency of the SPRresonance can be tuned by using different NPs sizes or interparticleseparations. The surface enhanced Raman scattering (SERS) response of the complex located in the gap of the NP aggregatesresults in an analytical SERS enhancement factor of 100,000. Thisfeature corroborates that the ruthenium complex is indeed locatedbetween nanoparticles. An additional confirmation of this fact hasbeen performed using Transmission Electron Microscopy (TEM), inwhich dimers, trimers and other aggregates where found. A kineticstudy of the NP aggregation process, followed by the evolution ofthe UV vis extinction spectra, has been also performed. The resultsshow that in a first stage it exist isolated NPs, later we can see theformation of dimers and trimers and i